Analysis of therapeutic effect of modified Yupingfeng powder combined with Yougui pill on COPD patients with deficiency of lung and kidney in remission period
- VernacularTitle:玉屏风散联合右归丸加减对肺肾两虚型COPD缓解期患者的疗效分析
- Author:
Yuhuan HUANG
1
;
Xiaohua HU
1
;
Jingjing ZENG
2
;
Dezhi HONG
3
;
Bing QIU
1
Author Information
1. Dept. of Internal Medicine，Fuzhou Hospital of Traditional Chinese Medicine，Jiangxi Fuzhou 344001，China
2. Center for Treatment and Prevention，the Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006，China
3. Dept. of Cardiovascular Medicine，Jiangxi Provincial People’s Hospital，Nanchang 330006，China
- Publication Type:Journal Article
- Keywords:
Yupingfeng powder;
Yougui pill;
chronic obstructive pulmonary disease;
deficiency of lung and kidney
- From:
China Pharmacy
2022;33(19):2384-2387
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the therapeutic effect of modified Yupingfeng powder combined with Yougui pill on patients with chronic obstructive pulmonary disease （COPD）with deficiency of lung and kidney in remission period . METHODS Ninety-two patients ，who were in remission of COPD and whose traditional Chinese medical syndromes belonged to deficiency of lung and kidney from Fuzhou Hospital of Traditional Chinese Medicine in Jiangxi province during May 2018-January 2020，were divided into control group and observation group according to random number table method ，with 46 patients in each group . Control group was treated with conventional western medicine （given Tiotropium bromide powder spray ，18 μg/inhalation，one dose per day ）；observation group was additionally treated with modified Yupingfeng powder decoction combined with Yougui pill （decocting one dose per day ，filtering 300 mL per time ，150 mL in the morning and afternoon ）on the basis of control group . After 8 weeks of treatment ，the clinical efficacy ，serum inflammatory factors and fibrosis indexes ，T cell subsets and lung function indexes，and the occurrence of adverse drug reactions were compared between 2 groups. RESULTS After treatment ，the total clinical effective rate of treatment （91.30%）in observation group was significantly higher than that of the control group （71.74%）； the levels of serum chemokine C -X3-C motif ligand 1，transforming growth factor β1，interleukin-6，matrix metalloproteinase -2 and tissue inhibitor of metalloproteinase -2 in observation group were significantly lower than control group ；there was statistical significance in CD 4+，CD3+，CD4+/CD8+，forced vital capacity ，the ratio of forced expiratory volume in the one second to forced vital capital （FEV1/FVC%）（P＜0.05）. The adverse drug reactions of the two groups were mainly gastrointestinal reactions and rashes. The incidence of adverse drug reactions in the observation group was 13.04%，and there was no statistical difference compared with control group （10.86%） （P＞0.05）. CONCLUSIONS Modified Yupingfeng powder combined with Yougui pill can reduce airway inflammation ， improve immunity and improve lung function of COPD patients with deficiency of lung and kidney in remission period ，and have good safety .
