A case -control study of the effects of surgical history on chemotherapy -induced nausea and vomiting
- VernacularTitle:手术史对化疗所致恶心呕吐影响的病例对照研究
- Author:
Bo SUN
1
;
Erfeng ZHANG
1
;
Lu CHEN
2
;
Xun LIU
3
;
Shufang LI
1
;
Huanqing MA
1
;
Lili PAN
1
;
Danna LIU
1
;
Huipin WANG
1
Author Information
1. Dept. of Pharmacy，the Third People’s Hospital of Zhengzhou/Tumor Hospital of Henan University，Zhengzhou 450099，China
2. Dept. of Internal Medicine of Respiratory Tract Tumor，the Third People’s Hospital of Zhengzhou/Tumor Hospital of Henan University，Zhengzhou 450099，China
3. Dept. of Pharmacy，Zhengzhou Second People’s Hospital，Zhengzhou 450006，China
- Publication Type:Journal Article
- Keywords:
surgical history;
chemotherapy-induced nausea and vomiting;
risk factors;
Logistic regression model
- From:
China Pharmacy
2022;33(19):2378-2383
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the influence of surgical history on chemotherapy -induced nausea and vomiting （CINV）. METHODS A retrospective case -control study was adopted ，with 824 patients undergoing chemotherapy as the object . A total of 27 items were collected ，including demographic data ，medical history data ，pre-chemotherapy data ，and chemotherapy treatment status. Logistic regression model was used to analyze the relationship between the history of surgery and the risk of CINV . The multiple models were constructed to correct potential confounding factors ，and subgroup analysis was performed on patients with surgical history . RESULTS The incidence of CINV was higher in patients with surgical history . The statistical result before adjustment was [OR＝1.72，95%CI（1.31，2.28），P＜0.001]；after adjusting potential confounding factors ，the statistical result was [OR＝1.78，95% CI（1.28，2.48），P＝0.001]. In the subgroup analysis ，the time between surgery and chemotherapy was different ， and the impact of surgical history on CINV was different ，and the results were statistically significant （P＝0.027）. The risk of CINV showed decreasing trend with the time ，and the results were statistically significant （P for trend ≤0.050）. Compared with patients who had not undergone surgery ，patients who had undergone surgery within one year had a higher risk of CINV [OR＝ 2.33，95%CI（1.52，3.59），P＜0.001]. CONCLUSIONS Patients with surgical history are more prone to CINV ，and the risk of CINV shows a downward trend in the length of time from surgery .
