Survey analysis of influential factors of medication compliance and adverse drug reactions of home -based patients with severe mental disorders in Jinshan district of Shanghai
- VernacularTitle:上海市金山区居家严重精神障碍患者用药依从性影响因素及药物不良反应调查分析
- Author:
Changqing MAO
1
;
Lianlian NIE
2
;
Yong WANG
3
;
Yanping ZHANG
3
;
Weihua SHEN
1
;
Cheng GUO
1
Author Information
1. Dept. of Pharmacy，Jinshan Branch of Shanghai Sixth People’s Hospital，Shanghai 201599，China
2. Shanghai Jinshan District Zhujing Community Health Service Center，Shanghai 201599，China
3. Shanghai Jinshan District Mental Health Center，Shanghai 201515，China
- Publication Type:Journal Article
- Keywords:
severe mental disorder;
home medication;
medication compliance;
adverse drug reactions;
pharmaceutical care
- From:
China Pharmacy
2022;33(19):2373-2377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the status quo ，influential factors of medication compliance and adverse drug reactions of home-based patients with severe mental disorders . METHODS Patients with severe mental disorders at home who were enrolled in the Shanghai mental health information management system in Jinshan district of Shanghai in Jan . 2022 were selected as the research objects . In combination with the relevant basic data registered in the information system and through face -to-face or telephone surveys by mental health doctors ，basic information ，medication compliance ，mental symptoms ，social function defects ， drug use information and adverse drug reactions of patients were understood . Univariate and multivariate Logistic regression analysis of medication compliance were performed . RESULTS Totally 2 684 questionnaires were distributed and 2 606 valid questionnaires were recovered ，with an effective recovery rate of 97.10%. The overall medication compliance of patients with severe mental disorders at home was 68.11%. The results of multivariate Logistic regression analysis showed that 51-60 years old ，unmarried， divorced or widowed ，partial social function defects ，no social function defects ， and use of third -generation antipsychotic drugs were the promotion factors of medication compliance ， （P＜0.05）；medical insurance ，non participation in work ，total number of hospitalizations of 1-4 times，total number of hospitalizations ≥ 5 times，general mental symptoms ，and use of second -generation antipsychotic drugs were the obstacles to medication compliance （P＜0.05）. The incidence of adverse drug reactions in patients with severe mental disorders a t home was 10.59%，mainly caused by second -generation antipsychotic drugs，and no new and serious adverse reactions were reported . CONCLUSIONS The medication compliance of patients with severe mental disorders at home is affected by many factors . It is urgent to need pharmacists ’participation to promote the standardization and rationality of patients ’medication.
