Clinicopathologic Manifestations of 36 Korean Patients with Acute Generalized Exanthematous Pustulosis: A Case Series and Review of the Literature.
- Author:
Min Jee CHOI
1
;
Hei Sung KIM
;
Hyun Jeong PARK
;
Chul Jong PARK
;
Jeong Deuk LEE
;
Jun Young LEE
;
Hyung Ok KIM
;
Young Min PARK
Author Information
- Publication Type:Original Article
- Keywords: Acute generalized exanthematous pustulosis; Clinicopathologic manifestation; Korean
- MeSH: Acute Generalized Exanthematous Pustulosis; Biopsy; Contrast Media; Drug Eruptions; Eosinophilia; Epidermis; Fever; Humans; Lacquer; Medical Records
- From:Annals of Dermatology 2010;22(2):163-169
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Acute generalized exanthematous pustulosis (AGEP) is a rare and severe subtype of drug eruption, characterized by acute, extensive, non-follicular, sterile pustules on an erythematous background, accompanied by fever and leukocytosis. OBJECTIVE: The purpose of this study was to characterize AGEP in Korean patients in terms of clinical, laboratory, and pathologic findings. METHODS: Thirty-six patients (M:F=17:19) with AGEP were identified from an extensive review of medical records over a 15 year period. All patient cases were confirmed by biopsy and fulfilled the diagnostic criteria. RESULTS: The patient ages ranged from 4~80 years (37.6+/-19.4). The incubation period was 1~23 days. The duration of disease was 5~14 days. Neutrophilia (36/36), high CRP (14/36), and eosinophilia (30/36) were common laboratory findings. A history of drug administration existed in 23 of 36 patients; herbal medications, lacquers and radiocontrast media were the unique causative drugs. Spongioform subcorneal or intraepidermal pustules in the epidermis was observed in all patients. Thirty-six patients were subdivided into 2 groups: group A (n=23) was strongly associated with known agents; and group B (n=13) had no identified causative agents. There was no significant difference between the 2 groups. CONCLUSION: Our results demonstrate the characteristic features of AGEP in Korean patients as follows: lower identification of causative agents; herbal medications, lacquers, and radiocontrast media were the main causative agents; and no significant differences existed between the 2 groups.
