Effects of Du Meridian Electroacupuncture on Growth Associated Protein- 43 Expression in Rats after Spinal Cord Injury

VernacularTitle:督脉电针对脊髓损伤大鼠生长相关蛋白43 表达的影响
Author: Binkui LI ; Bin ZENG ; Wei CHANG ; Dayi WANG ; Qi YANG ; Xiaoxun WANG ; Lianjun YU ; Tao LIU
Publication Type:Journal Article
Keywords: spinal cord injury, Du meridian electroacupuncture, growth associated protein-43
From: Chinese Journal of Rehabilitation Theory and Practice 2014;20(1):27-29
CountryChina
Language:Chinese
Abstract: Objective To study the effect of Du meridian electroacupuncture on growth associated protein-43 (GAP-43) expression in rats after spinal cord injury (SCI). Methods The SCI models were established with MASCIS Impactor at T11 segment in Sprague-Dawley rats. They were equally divided into control group (group A, n=18) and Du meridian electroacupuncture group (group B, n=18). Group B received electroacupuncture once a day since 1 week after SCI. They were evaluated with the Basso-Beattie-Bresnahan (BBB) score 1, 2, 4, 8 weeks after SCI. The mRNA and protein of GAP-43 was detected with RT-PCR and immunohistochemistry 2, 4, 8 weeks after SCI. Results Compared with group A, the BBB score, the expression of GAP-43 mRNA and protein increased in group B after SCI (P<0.01). Conclusion Du meridian electroacupuncture can promote the expression of GAP-43 after spinal cord injury.