Serological epidemiological characteristics of EV71 and pathogen spectrum of hand , foot and mouth disease in Deyang

Mi LI; Zhong-ping CHEN; Xin-ying YANG

白话标题:德阳地区手足口病病原谱分析及EV71血清学流行病学特征
作者: Mi LI ¹ ; Zhong-ping CHEN ¹ ; Xin-ying YANG ¹
作者信息

1. Department of Infectious Diseases , Deyang People's Hospital , Deyang , Sichuan 618000 , China
出版类型:Journal Article
关键字: Hand, foot and mouth disease; Pathogen spectrum; Enterovirus 71
来源: Journal of Public Health and Preventive Medicine 2022;33(5):144-147
国家China
语言:Chinese
摘要: Objective To explore the pathogen spectrum of hand, foot, and mouth disease (HFMD) in Deyang, and the serological epidemiological characteristics of enterovirus 71 (EV71). Methods The general clinical data and etiological data of 287 patients with HFMD in Deyang from June 2019 to June 2021 were statistically analyzed. Blood samples were collected to detect serum EV71 neutralizing antibodies by neutralization test. Results Among the 287 patients with HFMD, most of the critically ill patients were between 1 and 6 years old. There was a statistically significant difference in clinical classification between different age groups (P < 0.05). A total of 254 (88.50%) EV-positive cases were detected, including 131 (45.64%) positive for EV71, 98 (34.15%) positive for CVA16, and 25 (8.71%) positive for other EVs. The EV71 positive rate was higher in critically ill patients (P < 0.05). The positive rate of EV71 antibody increased with age within 15 years old, with statistically significant differences among different age groups (P < 0.05). Among the 287 serum samples, there were 156 (54.36%) samples with neutralizing antibody titer <1:8, 86 (29.97%) with titer between 1:8 and 1:32, and 45 (15.68%) with titer >1:32. Patients with EV71 neutralizing antibody titer>1:32 were over 15 years old. There were statistically significant differences in EV71 neutralizing antibody titer between different age groups (P<0.05). Conclusion The positive rate of EV is different in patients with different clinical types. EV71 and CVA16 are main pathogens of HFMD in Deyang. HFMD patients under 6 years old have lower EV71 antibody level. It is recommended to strengthen EV71 vaccination for children under 6 years old.