Drug resistance characteristics of proteus mirabilis in cooked meat in Zhongshan City in 2017 -2020
10.3969/j.issn.1006-2483.2022.05.032
- VernacularTitle:2017—2019年中山市熟肉中奇异变形杆菌耐药特征分析
- Author:
Zhi-ying YE
1
;
Can-quan WU
1
;
Zhan-hong YUAN
1
Author Information
1. Zhongshan Center for Disease Control and Prevention , Zhongshan , Guangdong 518400 , China
- Publication Type:Journal Article
- Keywords:
Proteus mirabilis;
Drug resistance;
Extended spectrum β-lactamases
- From:
Journal of Public Health and Preventive Medicine
2022;33(5):137-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the contamination of Proteus mirabilis in cooked meat products sold in Zhongshan City from 2017 to 2020, and to analyze its drug resistance characteristics. Methods The detected positive strains of Proteus mirabilis were analyzed for drug resistance. The suspected strains of producing extended spectrum β-lactamases were detected by preliminary screening, then its genes were detected by using molecular biology methods and were finally sequenced. Results Among the 184 strains of Proteus mirabilis detected within 4 years, 117 strains were multi-drug resistant. 184 strains of Proteus mirabilis were highly resistant to tetracycline, polymyxin, minocycline, doxycycline and cefazolin, and they had a high sensitivity rate to ampicillin-sulbactam, cefotaxime, Ceftazidime, cefoxitin, gentamicin, ciprofloxacin, amoxicillin-clavulanic acid, and levofloxacin. In addition, all strains were sensitive to amikacin, meropenem and imipenem.Only one strain was isolated to produce extended spectrum β- Lactamase bacteria. Conclusion Comparing 2020 with 2017, the resistance rate of Proteus mirabilis in cooked meat to most antibiotics showed a downward trend, and the detection rate of multi-drug resistant bacteria decreased year by year. Compared with the clinically detected strains, the drug resistance rate of the detected strains in cooked meat is generally lower than that of the clinical strains. The monitoring of drug resistance of Proteus mirabilis should be continuously strengthened, which is of great significance for guiding the rational use of drugs in clinical practice and delaying the emergence of drug-resistant strains.
