Predictive value of neutrophil to lymphocyte ratio combined with BNP in elderly patients with heart failure complicated with pulmonary infection
10.12206/j.issn.2097-2024.202112010
- VernacularTitle:中性粒细胞和淋巴细胞比值联合B型利钠肽对老年心力衰竭合并肺部感染的预测价值
- Author:
Jie ZHANG
1
;
Shengwu CHAO
2
;
Jishun YANG
2
Author Information
1. School Infirmary of Fudan University, Shanghai 200433, China.
2. .
- Keywords:
heart failure;
pulmonary infection;
NLR;
BNP
- From:
Journal of Pharmaceutical Practice and Service
2022;40(5):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive value of neutrophil to lymphocyte ratio(NLR) and B-type natriuretic peptide (BNP) in elderly patients with heart failure complicated with pulmonary infection. Methods 178 heart failure patients in our hospital from June 2018 to May 2020 were selected as the research objects, and they were divided into pulmonary infection group (n=92) and non-pulmonary infection group (n=86) according to whether they were complicated with pulmonary infection. The differences of NLR and BNP levels and other clinical indicators between the two groups were compared. Univariate and multivariate Cox regression were used to analyze the influence of NLR and BNP levels on heart failure complicated with pulmonary infection. The predictive value of NLR combined with BNP on heart failure complicated with pulmonary infection was analyzed by receiver operating characteristic (ROC) curve. Results Multivariate logistic regression analysis showed that NLR (OR=7.606, 95% CI: 3.123-18.526) and BNP (OR=4.264, 95% CI: 1.682-10.811) were independent risk factors of elderly heart failure complicated with pulmonary infection after adjusting for other related variables. Pearson correlation analysis showed that BNP level was positively correlated with NLR level (r=0.400, P<0.001). The area under ROC curve of NLR, BNP and NLR+BNP in predicting pulmonary infection in elderly patients with heart failure was 0.810, 0.756 and 0.838, respectively. Conclusion BNP and NLR are independent risk factors of elderly patients of heart failure with pulmonary infection .The combined detection of BNP and NLR has predictive value for those patients.
