Anti-inflammatory and analgesic study of Yinlian Tongfeng granules on adjuvant arthritis rats
10.12206/j.issn.2097-2024.202103005
- VernacularTitle:茵连痛风颗粒对佐剂性关节炎大鼠的抗炎镇痛作用研究
- Author:
Jing LIU
1
;
Yi XU
1
;
Tiejun WU
1
;
Jin HUANG
1
Author Information
1. Department of Pharmacy, Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
- Keywords:
Yinlian Tongfeng granules;
adjuvant arthritis;
rheumatoid arthritis;
cytokines
- From:
Journal of Pharmaceutical Practice and Service
2022;40(5):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relieving effect of Yinlian Tongfeng granules on adjuvant arthritis rats. Methods A complete Freund adjuvant model was built for this study. 48 rats were randomly divided into control group, model group, Yinlian Tongfeng granules high, medium and low dose group (15.4g/kg, 7.7g/kg, 3.8g/kg). After the drug intervention, arthritis index, ankle swelling rate, formaldehyde induced pain score were recorded. Elisa method was used to detect IL-4, IL-10 and the content of PK1, PK2. The pathological changes of toe pad in rats were observed. Results Compared with the model control group, Yinlian Tongfeng granules groups significantly inhibited the ankle swelling, reduced the pain reaction caused by formaldehyde (P<0.01), significantly increased the content of anti-inflammatory factors IL-4 and IL-10 (P<0.01), and decreased the content of PK1 and PK2 (P<0.01). Toe edema and lymphocyte infiltration were alleviated. Conclusion Yinlian Tongfeng granules have a significant inhibitory effect on adjuvant arthritis, suggesting that it has a potential therapeutic application for rheumatoid arthritis.
