Research progress of the classic prescription Tianwang buxin dan in the treatment of insomnia
- VernacularTitle:经典名方天王补心丹治疗失眠的研究现状
- Author:
Qian ZHAO
1
,
2
;
Jingcao LI
2
;
Ting HUANG
1
;
Qian HE
1
;
Yinping LI
1
;
Xiao WANG
1
Author Information
1. Animal Laboratory Center，Guangzhou University of Chinese Medicine，Guangzhou 511400，China
2. Institute of Toxicology and Medical Countermeasures/State Key Laboratory of Pharmacology and Toxicology，Academy of Military Medical Sciences，Beijing 100089，China
- Publication Type:Journal Article
- Keywords:
Tianwang buxin dan;
insomnia;
theoretical basis of traditional Chinese medicine;
couplet medicinals
- From:
China Pharmacy
2022;33(18):2295-2298
- CountryChina
- Language:Chinese
-
Abstract:
Tianwang buxin dan （TWBXD），as a classic prescription for treating insomnia ，in forms of tablet ，drop pill ，patch and others ，has been widely used in clinical practice . Its compound prescription and single ingredient can play a calming and tranquilizing role by regulating neurotransmitters ，inhibiting oxidative stress reaction and the expression of inflammatory factors . Based on the theory of traditional Chinese medicine and combined with modern pharmacological research ，this paper reviews single ingredient and active components of TWBXD ，calming and tranquilizing role of related couplet medicinals . The results showed that the single ingredients such as Rehmannia glutinosa ，the seeds of Zizyphus jujube ，the seeds of Platycladus orientalis ，Angelica sinensis，Schisandra chinensis ，Poria cocos and their effective components as well as related couplet medicinals of Z. jujube could improve the insomnia symptoms in different degrees . Except that the mechanism of the seeds of P. orientalis has not been studied ， other ingredients mainly act on nervous -endocrine-immune system . They can play the sedative and hypnotic effects by regulating neurotransmitters，inflammatory factors and oxidation .
