Application of biomimetic nano drug delivery system of macrophage membrane in disease targeted therapy
- VernacularTitle:巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用
- Author:
Chanlian LI
1
;
Jiamin SONG
1
;
Meiling CHEN
2
;
Xiaoliang REN
2
;
Meng WANG
1
Author Information
1. State Key of Component -based Chinese Medicine，Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
2. School of Chinese Materia Medica，Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
- Publication Type:Journal Article
- Keywords:
macrophage;
nanoparticles coated with cell membrane;
biomimetic delivery system;
targeted therapy
- From:
China Pharmacy
2022;33(18):2290-2294
- CountryChina
- Language:Chinese
-
Abstract:
In recent years ，biomimetic nanodelivery system based on cell membrane coating has developed rapidly and shows better biocompatibility and efficacy than traditional nanodelivery systems in a variety of diseases . Macrophages，as members of the immune system ，are closely related to the occurrence and development of a variety of diseases . Macrophages are derived from monocytes and can be polarized into M 1 and M 2 types after corresponding stimulation ： M1 macrophages involved in the proinflammatory reaction and M 2 macrophages involved in the inflammatory reaction . This paper reviews the application status of biomimetic nanoparticles coated with macrophage membrane in disease targeted therapy in recent years . Biomimetic nanoparticles coated with macrophage membrane has shown its high targeting and low immunogenicity in the treatment of malignant tumors （breast cancer ，colorectal cancer ，melanoma，glioma），Alzheimer’s disease ，liver ischemia -reperfusion injury ，atherosclerosis and so on . However，the research of Biomimetic nanoparticles coated with macrophage membrane currently focuses on anti -tumor research and is still in the laboratory research stage .
