Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A
- VernacularTitle:环孢素A个体化用药临床预后的实验室检查指标研究进展
- Author:
Jinwei HU
1
,
2
;
Huaijun ZHU
1
;
Qianying LAO
1
,
2
;
Danying LI
1
Author Information
1. Dept. of Pharmacy，Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School，Nanjing 210008，China
2. Drum Tower Clinical College of Integrated Chinese and Western Medicine，Nanjing University of Chinese Medicine，Nanjing 210008，China
- Publication Type:Journal Article
- Keywords:
cyclosporine A;
therapeutic drug monitoring;
clinical effi cacy;
safety;
laboratory examination index
- From:
China Pharmacy
2022;33(18):2285-2289
- CountryChina
- Language:Chinese
-
Abstract:
Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ，the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects ：the cyclosporine A concentration of peripheral blood mononuclear cells ，calcineurin activity ，T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ，which can make up for the insufficiency of blood drug concentration monitoring ，and the clinical practicability needs to be further improved .
