Efficacy and safety of kidney -tonifying Chinese patent medicine combined with PDE 5 inhibitor in the treatment of erectile dysfunction ：a network meta -analysis
- VernacularTitle:补肾类中成药联合PDE5抑制剂治疗勃起功能障碍有效性与安全性的网状Meta分析
- Author:
Zhen WANG
1
;
Lijuan ZHANG
1
;
Xujie LI
1
;
Ziyang ZHOU
1
;
Miaoxiu LI
1
;
Cong’an WANG
2
;
Yongquan WANG
3
Author Information
1. College of Acupuncture and Massage，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. Dept. of Chinese Osteo -traumatology，Neck，Shoulder，Waist and Leg Pain Hospital Affiliated to Shandong First Medical University，Jinan 250000，China
3. Dept. of Traditional Chinese Medicine，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250014，China
- Publication Type:Journal Article
- Keywords:
erectile dysfunction;
kidney-tonifying Chinese patent medicine;
phosphodiesterase type 5 inhibitor;
meta-analysis
- From:
China Pharmacy
2022;33(18):2271-2276
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically review the efficacy and safety of kidney -tonifying Chinese patent medicine combined with phosphodiesterase type 5（PDE5）inhibitors in the treatment of erectile dysfunction （ED），and to provide evidence - based reference for clinical medication . METHODS Retrieved from PubMed ，Embase，Cochrane Library ，Web of Science ，VIP， China Biomedical Literature Database ，CNKI and Wanfang database ，randomized controlled trials （RCTs）of kidney -tonifying Chinese patent medicine combined with PDE 5 inhibitors（trial group ）versus PDE 5 inhibitors or kidney -tonifying Chinese patent medicine alone （control group ）were collected . The search period was from the establishment of the database to February 15，2022. After literature screening and data extraction ，the risk of bias assessment tool recommended in Cochrane System Reviewer ’s Handbook 6.1.0 was used to evaluate the quality of the included literature ；Stata 16.0 software was used for network meta -analysis； and the funnel plot was used for publication bias analysis . RESULTS A total of 23 RCTs were included ，with a total of 2 417 patients， involving 8 kinds of Chinese patent medicines ， including Congrong yishen granule ，Canrong zhutian capsule ， Compound xuanju capsule ， Huanshao capsule ， Shanhaidan granule， Shengjing capsule ， Shisanwei ziyin zhuangyang capsule，Shugan yiyang capsule . The results of network meta analysis showed that in terms of total effective rate ，Compound xuanju capsule combined with PDE 5 inhibitor，Shengjing capsule combined with PDE 5 inhibitor，Shugan yiyang capsule combined with PDE 5 inhibitor had higher total effective rate ；in terms of international index of erectile function 5，the scores of Compound xuanju capsule combined with PDE 5 inhibitor，Congrong yishen granule combined with PDE 5 inhibitor，and Canrong zhutian capsule combined with PDE 5 inhibitor were higher ；in terms of safety ，the incidence of adverse drug reactions caused by Huanshao capsule ，Shanhaidan granule and Shugan yiyang capsule were lower . CONCLUSIONS Kidney-tonifying Chinese patent medicine combined with PDE 5 inhibitor can improve the erectile function of ED patients and reduce the occurrence of adverse drug reactions . In terms of efficacy and safety ，Compound xuanju capsule combined with PDE 5 inhibitor is the best .
