Relationship between chronic constipation and brain-gut microflora axis.
10.3760/cma.j.cn441530-20210921-00377
- VernacularTitle:慢性便秘与脑肠菌群轴的关系
- Author:
Qi Yi CHEN
1
;
Ning LI
1
;
Jun JIANG
2
Author Information
1. Department of Colorectal Disease, Shanghai Tenth People's Hospital, Clinical Research Center for Digestive Diseases, Tongji University, Shanghai 200072, China.
2. Institute of General Surgery, East War Zone Hospital of PLA, Nanjing 210002, China.
- Publication Type:Journal Article
- Keywords:
Brain-gut axis;
Chronic constipation;
Intestinal flora
- MeSH:
Brain;
Constipation;
Enteric Nervous System;
Gastrointestinal Microbiome;
Humans
- From:
Chinese Journal of Gastrointestinal Surgery
2021;24(12):1048-1053
- CountryChina
- Language:Chinese
-
Abstract:
The role of the brain-gut microbiota axis in functional gastrointestinal diseases has been gradually recognized. According to the ROME IV diagnostic criteria, functional gastrointestinal diseases are classified as diseases caused by abnormal brain-gut interaction. This concept is of great significance to the change of diagnosis and treatment paradigm of functional gastrointestinal diseases. Chronic constipation is the most common functional gastrointestinal disease. The pathogenesis of chronic constipation is closely related to the imbalance of intestinal flora, the abnormality of enteric nervous system and neurotransmitter in brain. Therefore, in the diagnosis and treatment of chronic constipation, enough attention should be paid to the concept of integration of brain-gut microflora axis, but the clinical application of brain-gut microflora axis is still limited. This may be one of the factors for high incidence but poor treatment efficacy of chronic constipation. Based on the global research progress and our clinical experience, this article expounds the clinical significance of the brain-gut microbiota axis in chronic constipation.
