Advances and challenges in neoadjuvant treatment for colorectal cancer liver metastasis.
10.3760/cma.j.cn.441530-20200423-00241
- VernacularTitle:结直肠癌肝转移新辅助治疗研究进展及挑战
- Author:
Zhi Zhong PAN
1
Author Information
1. Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Liver metastases;
Neoadjuvant therapy;
Research progress
- MeSH:
Chemotherapy, Adjuvant;
Colorectal Neoplasms/drug therapy*;
Humans;
Liver Neoplasms/drug therapy*;
Neoadjuvant Therapy;
Neoplasm Recurrence, Local
- From:
Chinese Journal of Gastrointestinal Surgery
2021;24(10):919-924
- CountryChina
- Language:Chinese
-
Abstract:
Liver metastasis is the leading cause of death in patients with colorectal cancer. Since surgical resection alone has a high postoperative recurrence rate, neoadjuvant therapy as an important means is widely applied in order to reduce recurrence and improve survival. Progress has been achieved in many aspects of neoadjuvant therapy in colorectal cancer liver metastasis, such as eligible patients selection, optimal regimens and courses of chemotherapy. However, controversies still remain regarding the standards of resectability of lesions and the application of targeted drugs. Individualized treatments could be developed based on multidisciplinary teamwork to achieve the goal of 'resources integration and treatment stratification'.
