Advances in basic and translational research in neuroendocrine neoplasms.
10.3760/cma.j.cn.441530-20210705-00261
- Author:
Shun Rong JI
1
;
Xiao Wu XU
1
;
Xian Jun YU
1
Author Information
1. Center for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Pancreatic Cancer Institute, Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
Model;
Multi-omics;
Neuroendocrine neoplasms;
Tumor microenvironment
- MeSH:
Animals;
DNA Copy Number Variations;
Mice;
Neoplasm Recurrence, Local;
Neuroendocrine Tumors/genetics*;
Translational Research, Biomedical;
Tumor Microenvironment
- From:
Chinese Journal of Gastrointestinal Surgery
2021;24(10):867-874
- CountryChina
- Language:Chinese
-
Abstract:
With the development of diagnostic techniques and the improvement of people's living standards, the detection rate of neuroendocrine tumor has been increasing and people are paying more and more attention to it. With multiple treatment modalities, the clinical research progress of neuroendocrine tumor is remarkable. However, due to the tumor heterogeneity, metastasis and recurrence of neuroendocrine tumor remains a difficult problem for clinicians. The efficacy of neuroendocrine tumor still needs to be improved. Therefore, the biological behavior of neuroendocrine tumor needs to be further studied. In recent years, with the development of molecular biology, the basic and transformation research of neuroendocrine tumor has made some progress. In this paper, we focus on the hot topics of neuroendocrine tumor, such as multiomics (copy number variation, genomics, transcriptomics), tumor microenvironment (immune microenvironment, tumor microvasculature, tumor-associated fibroblasts, etc.), preclinical research model construction (cell lines, organoids, patient derived xenograft models, genetically engineered mice), etc. Specifically, the related clinical transformation significance will be elaborated.
