Current status of research on the role of fibronectin in the progression of posterior capsular opacification fibrosis

VernacularTitle:纤维粘连蛋白在后发性白内障纤维化进展中的作用研究现状
Author: Wen-Hao XU ¹ ; Shu-Hua LIN ¹ ; Yu-Jie JIA ¹ ; Jian ZHAO ¹ ; Fa-Li JIA ¹ ; Wan-Ying CAO ¹ ; Li-Lan JIANG ¹ ; Ying-Jun LI ¹
Author Information

1. Department of Ophthalmology, the Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Publication Type:Journal Article
Keywords: posterior capsular opacification; fibronection; lens epithelial cells; fibrosis; extracellular matrix
From: International Eye Science 2022;22(10):1630-1633
CountryChina
Language:Chinese
Abstract: Posterior cataract opacification(PCO)is the epithelial-mesenchymal transformation(EMT)of residual lens epithelial cells(LECs)after cataract surgery, resulting in opaque scar which is one of the main complications of cataract surgery. A large amount of fibronectin(FN)produced by LECs after cataract surgery binds to a variety of cell surface receptors, matrix components and growth factors to regulate cell behavior. The purpose of this article is to review the literatures on the treatment of PCO targeting fibronectin and provide references for clinical treatment of PCO. In this paper, the research status of fibronectin in PCO in recent years is reviewed.