Comparison of Xpert® MTB/RIF with microscopy and cytology in the diagnosis of tuberculous lymphadenopathy in patients presenting for fine needle aspiration biopsy at the Port Moresby General Hospital
- Author:
Rodney Itaki
;
Jacklyn Joseph
;
Ruth Magaye
;
Jennifer Banamu
;
Karen Johnson
;
Francis Bannick
;
Evelyn Lavu
;
Henry Welch
- Publication Type:Journal Article
- From:
Papua New Guinea medical journal
2019;62(3-4):107-113
- CountryPapua New Guinea
- Language:English
-
Abstract:
SUMMARY
Patients with a clinical diagnosis of tuberculous lymphadenitis (TBLN) undergoing fine needle aspiration (FNA) biopsy at Port Moresby General Hospital (PMGH) were recruited in a pilot study to compare Xpert® MTB/RIF (Xpert) with microscopy and cytology. From a total of 1080 patients attending the FNA clinic during the study period 107 were recruited, of whom 105 were analysed. Xpert detected Mycobacterium tuberculosis in 65/105 subjects (62%), acid-fast bacilli (AFB) were found in 35/105 (33%) and cytology was positive in 59/105 (56%). 3 of 7 samples unsuitable for microscopy and 9 of the 28 cases (32%) initially classified as non-TBLN were Xpert positive. Xpert was comparable to cytology but more sensitive than microscopy. Xpert also detected multidrug-resistant tuberculosis (MDR-TB) TBLN cases. The results demonstrated that FNA samples are suitable for Xpert analysis at PMGH to diagnose TBLN, which has the added advantage of detecting MDR-TB.
