Research progress on the role of transforming growth factor-β in tooth and craniofacial bone development and diseases
10.12016/j.issn.2096-1456.2022.12.008
- Author:
CAI Lang
1
,
2
,
3
;
XIE Jing
1
,
2
,
4
;
ZHOU Xuedong
1
,
2
,
3
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases &
3. Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
4. West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
TGF-β;
Smad signaling;
tooth development;
enamel;
dentin;
jaw;
temporomandibular joint;
bone development;
cleft palate
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(12):884-889
- CountryChina
- Language:Chinese
-
Abstract:
Dental and craniofacial bone development is a highly coordinated process that is tightly controlled by genetics and influenced by complex environments. The abnormal regulation of many development-related signaling molecules may lead to abnormal tooth development, severe craniofacial bone formation disorders, and developmental deformities. Transforming growth factor-β (TGF-β) is widely expressed in vivo and participates in many cellular biological processes, showing complex regulatory roles in mammalian craniofacial bone growth and tooth development. In tooth development, abnormal TGF-β signaling can lead to the failure of tooth germ formation, and its deletion mutation can directly affect odontoblast differentiation and enamel formation defects. However, the current research on TGF-β mainly focuses on the early stage of tooth development, and a comprehensive and systematic study of TGF-β-related tooth development is lacking. TGF-β signal transduction mainly controls the development of teeth and craniofacial bone by regulating the expression of development-related molecules via the classical Smad-dependent signaling pathway. In addition, the nonclassical mitogen-activated protein kinase (MAPK) pathway also participates in this process. Abnormal TGF-β signaling may cause jaw development disorders, temporomandibular joint dysplasia and inflammation, and cleft palate. Because the specific regulatory mechanism of TGF-β in craniofacial bone development has not been fully elucidated, its specific application in the treatment of related diseases is also greatly limited. This paper describes the new research progress of TGF-β in the development of teeth, jaws, temporomandibular joints and palate as well as related diseases.
- Full text:转化生长因子-β_在牙齿及颅面骨发育和疾病中作用的研究进展.pdf
