Clinical Research on Effectiveness of Mitomycin C on Primary Pterygium With Limbal-Conjunctival Autograft.
10.3341/jkos.2009.50.7.996
- Author:
Byeong Hee LEE
1
;
Jong Wook LEE
;
Young Jeung PARK
;
Kyoo Won LEE
Author Information
1. Cheil Eye Hospital, Daegu, Korea. eyepark9@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Limbal-conjunctival autograft;
Mitomycin C;
Pterygium
- MeSH:
Conjunctiva;
Cornea;
Eye;
Follow-Up Studies;
Granuloma;
Hemorrhage;
Humans;
Mitomycin;
Pterygium;
Recurrence;
Tissue Donors
- From:Journal of the Korean Ophthalmological Society
2009;50(7):996-1004
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effectiveness of Mitomycin C used as a combined therapy along with limbal-conjunctival autograft for primary pterygium. METHODS: Thirty eyes of 29 patients received Mitomycin C (0.02% MMC 3 minutes) with limbal-conjunctival autograft, and 30 eyes of 28 patients received limbal-conjunctival autograft alone. Recurrence and complications were evaluated in the patients at 2 weeks, 1, 3, 6 and 12 months postoperatively. RESULTS: Mean follow-up periods were 13.4+/-2.1 and 13.9+/-2.9 months, respectively. Between the two groups, recurrence in the conjunctiva or the cornea was not observed during the follow-up period. In the Mitomycin C use group, complications included a granuloma at the donor site (1 eye, 3.3%), wound dehiscence (2 eyes, 6.7%), and subgraft hemorrhage (2 eyes, 6.7%). In comparison, in the group treated with limbal-conjunctival autograft alone, complications included granuloma at the donor site (1 eye, 3.3%), pseudopterygium at the donor site (1 eye, 3.3%), wound dehiscence (3 eyes, 10%), and subgraft hemorrhage (2 eyes, 6.7%). CONCLUSIONS: The use of Mitomycin C as an adjuvant therapy has no significant effect on the recurrence rate in primary pterygium with limbal-conjunctival autograft.
