Mechanism of rebalanced hemostasis in liver cirrhosis and the timing of blood transfusion and anticoagulation
10.3969/j.issn.1001-5256.2022.09.037
- VernacularTitle:肝硬化止血再平衡的机制及输血、抗凝时机的选择
- Author:
Huan MA
1
;
Mei HAN
1
;
Yue ZHANG
1
;
Chunmeng JIANG
1
;
Hui LIU
1
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Hemorrhage;
Blood Transfusion;
Anticoagulants
- From:
Journal of Clinical Hepatology
2022;38(9):2141-2145
- CountryChina
- Language:Chinese
-
Abstract:
Reconstructed rebalanced hemostasis exists in patients with liver cirrhosis, while such balance is unstable and can be easily broken by stress factors, which may lead to bleeding or thrombosis. There is a lack of effective strategies to prevent and solve the disrupted balance in clinic due to the complex pathogenesis of rebalanced hemostasis, limited testing methods, and insufficient awareness among clinicians. With reference to the articles in recent years, this article summarizes the mechanism of rebalanced hemostasis in liver cirrhosis and the causes of bleeding and thrombosis and discuss the association between blood transfusion and rebalanced hemostasis and the selection of anticoagulant drugs during thrombosis, in order to provide a theoretical basis and new ideas for solving related issues in clinical practice.
