Clinical analysis of 14 cases of head and neck carcinosarcoma.
10.3760/cma.j.cn115330-20201003-00782
- VernacularTitle:头颈部癌肉瘤14例临床分析
- Author:
Jun Ling WANG
1
;
Li LIU
2
;
Ru Jia JIN
3
;
Jian Zhong SANG
1
;
Hua CAO
1
;
Jin SUN
1
;
Zhi Feng ZHANG
4
;
Lei CHEN
5
;
Xiang Cen GUO
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
2. Department of Medicine, Henan Medical College, Zhengzhou 451191, China.
3. Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
4. Department of Otorhinolaryngology Head and Neck Surgery, the Third People's Hospital of Zhengzhou, Zhengzhou 450000, China.
5. Department of Otolaryngology, Changyuan City Hospital of Traditional Chinese Medicine, Changyuan 453400, Henan Province, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinosarcoma/therapy*;
Female;
Humans;
Kaplan-Meier Estimate;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Prognosis;
Retrospective Studies
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2021;56(4):381-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological characteristics, treatment and prognosis of head and neck carcinosarcoma. Methods: The clinical data of 14 patients with head and neck carcinosarcoma treated in the First Affiliated Hospital of Zhengzhou University from January 2010 to May 2020 were retrospectively analyzed, including 11 males and 3 females, with age range from 30 to 72 years old. Clinicopathological characteristics, treatments and follow-up results of patients were evaluated. Kaplan-Meier method was used to estimate the cumulative survival rate. Results: Histopathological examination showed the co-existence of malignant epithelial and mesenchymal components in all cases. Immunohistochemical staining of 13 cases showed cytokeratin and epithelial membrane antigens were positively expressed in the epithelial areas, whereas vimentin was positive in the malignant mesenchymal tissue area. Among 14 cases, 5 cases were treated with surgery, 3 cases with surgery and radiotherapy, and 6 cases with surgery, radiotherapy and chemotherapy. The follow-up time was 2-81 months, with a median follow-up time of 22.5 months. Except for one patient who was lost to follow-up in 21 months after treatment, among the remaining 13 patients, 4 patients had recurrence, 8 patients died, and 5 patients had a tumor-free survival. The Kaplan-Meier analysis showed that the 1, 3, and 5-year cumulative survival rates of 14 patients with head and neck carcinosarcoma were 64.3%, 57.1%, and 42.9%, respectively. Conclusions: Carcinosarcoma of the head and neck is rare in clinic, histopathological and immunohistochemical examinations are important basis for diagnosis, and surgery is a preferred treatment. Carcinosarcoma of the head and neck has a poor prognosis, and patients should be followed up for a long time.
