Prevalence and risk factors of Giardia lamblia infections among colorectal cancer patients in Henan Province
10.16250/j.32.1374.2022054
- VernacularTitle:河南省结直肠癌患者蓝氏贾第鞭毛虫感染 及危险因素分析
- Author:
Hui-hui CHEN
1
,
2
;
Yan DENG
2
,
3
;
Zhi LI
4
;
Zhen-lei WANG
4
;
Zeng-ci RUN
4
;
Ting ZHANG
1
;
Yu-chun CAI
1
;
Hong-wei ZHANG
3
;
Zhu-hua HU
5
;
Jun-hu CHEN
1
;
Li-guang TIAN
1
;
Jian LI
4
Author Information
1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, School of Global Health, Chinese Center for Tropical Diseases and Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
2. Co-first authors
3. Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan 450016, China
4. Henan Cancer Hospital, Zhengzhou, Henan 450003, China
5. Research Base of National Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory of Animal Origin and Vector-borne Infectious Diseases of Jiangxi Province, Nanchang Center for Disease Control and Prevention, Jiangxi Province, China
- Publication Type:Journal Article
- Keywords:
Giardia lamblia;
Colorectal cancer;
Genotype;
Risk factor;
Henan Province
- From:
Chinese Journal of Schistosomiasis Control
2022;34(4):370-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiological characteristics and identify the risk factors of Giardia lamblia infections among patients with colorectal cancer in Henan Province. Methods A cross-sectional study was performed for questionnaire surveys among colorectal cancer patients in Henan Cancer Hospital during the period from March to July, 2021. Patients’ stool samples were collected, and the triosephosphate isomerase (tpi) gene of G. lamblia was amplified in stool samples using nested PCR assay to characterize the parasite genotype. Univariate analysis and multivariate logistic regression analyses were employed to identify the risk factors of G. lamblia infections among colorectal cancer patients. Results A total of 307 colorectal cancer patients were investigated, including 176 males (57.3%) and 131 females (42.7%). PCR assay detected 8.1% [95% confidential interval (CI): (0.056, 0.117)] prevalence of G. lamblia infections among the study subjects, and there was no significant difference in the prevalence between men [9.1%, 95% CI: (0.057, 0.143)] and women [6.9%, 95% CI: (0.037, 0.125)] (χ2 = 0.495, P = 0.482). In addition, there was no age-specific prevalence of G. lamblia infections among the participants (χ2 = 1.534, P = 0.675). Multivariate logistic regression analysis identified use of septic tanks [odds ratio (OR) = 3.336, 95% CI: (1.201, 9.267)], daily use of well water [OR = 3.042, 95% CI: (1.093, 8.465)] and raising livestock [OR = 3.740, 95% CI: (1.154, 12.121)] as risk factors of G. lamblia infections among colorectal cancer patients, and the prevalence of abdominal pain was significantly greater in colorectal cancer patients with G. lamblia infections than in those without infections (P = 0.017). Among the 25 patients with G. lamblia infections, assemblage A was characterized in 24 (96.0%) cases and assemblage B in one case (4.0%). Conclusions The prevalence of G. lamblia is high among colorectal cancer patients in Henan Province, and assemblage A is the dominant genotype of G. lamblia. Use of septic tanks, daily use of well water and raising livestock are risk factors of G. lamblia infections among patients with colorectal cancer.
