Mechanism of Toxic Chinese Medicinals Against Esophageal Cancer： A Review
10.13422/j.cnki.syfjx.202202024
- VernacularTitle:有毒中药抗食管癌作用机制研究进展
- Author:
Zhendong GAO
1
;
Fuchun SI
2
Author Information
1. Traditional Chinese Medicine （TCM，Zhongjing） School， Henan University of Chinese Medicine， Zhengzhou 450046， China
2. Henan Provincial Key Laboratory of Prescription-Syndrome Signal TCM， International Joint Laboratory of Prescription-syndrome Signal Transduction of TCM in Henan Province， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
toxic Chinese medicinal;
mechanism;
meridian tropism;
advance
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(20):274-282
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer ranks the seventh and sixth in morbidity and mortality among the malignant tumors， respectively. In traditional Chinese medicine， toxic medicinals are commonly used to enhance the efficacy on esophageal cancer. In recent years， as natural drugs have become the focus of research on anti-tumor drugs， toxic Chinese medicinals have received wide attention. It has been found that a variety of toxic Chinese medicinals have significant anti-esophageal cancer effect. In this study， articles on the treatment of esophageal cancer were retrieved from SinoMed， China National Knowledge Infrastructure （CNKI）， Wanfang Data， and VIP， and the toxic Chinese medicinals in the articles were summarized. It was found that the toxic Paridis Rhizoma， Gekko， Cremastrae Pseudobulbus Pleiones Pseudobulbus， Scolopendra， Hirudo， Sophorae Tonkinesis Radix et Rhizoma， Scorpio， and Bufonis Corium were mainly used for the treatment of this cancer. They can be classified into the heat-clearing and toxin-removing medicinals， toxin-counteracting medicinals， phlegm-resolving medicinals， and blood-activating and stasis-resolving medicinals. Most of them were pungent （19，52.78%） or bitter （17，47.22%）. The majority had the meridian tropism toward liver （25， 69.44%）， spleen （13， 36.11%）， and lung （12， 33.33%）. According to the research on the above commonly used toxic Chinese medicinals， most of them have anti-tumor effect and some have been reported to have anti-esophageal cancer effect. The mechanism is mainly the inhibition of proliferation. To be specific， they exert the anti-cancer effect by suppressing the proliferation， migration， and differentiation of cancer cells， inducing cell cycle arrest， and activating B-cell lymphoma/leukemia-2 （Bcl-2）-associated X protein （Bax）/Bcl-2/Caspase signaling pathway to induce apoptosis. In this paper， the commonly used toxic Chinese medicinals for the treatment of esophageal cancer were statistically analyzed， and the mechanisms were summarized， in order to provide a reference for the clinical rational use of toxic Chinese medicinals and the research on the mechanisms for their efficacy.
