Bivariate heritability estimation of resting heart rate and common chronic disease based on extended pedigrees.
10.19723/j.issn.1671-167X.2020.03.006
- Author:
Hong Chen ZHENG
1
;
En Ci XUE
1
;
Xue Heng WANG
1
;
Xi CHEN
1
;
Si Yue WANG
1
;
Hui HUANG
1
;
Jin JIANG
1
;
Ying YE
2
;
Chun Lan HUANG
3
;
Yun ZHOU
4
;
Wen Jing GAO
1
;
Can Qing YU
1
;
Jun LV
1
;
Xiao Ling WU
3
;
Xiao Ming HUANG
3
;
Wei Hua CAO
1
;
Yan Sheng YAN
2
;
Tao WU
1
;
Li Ming LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Department of Local Disease Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China.
3. Department of Hygiene, Nanjing County Center for Disease Control and Prevention, Nanjing 363600 Fujian, China.
4. Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.
- Publication Type:Journal Article
- Keywords:
Diabetes;
Heritability;
Hypertension;
Pedigree;
Resting heart rate
- MeSH:
Blood Pressure;
Chronic Disease;
Female;
Heart Rate;
Humans;
Hypertension;
Male;
Middle Aged;
Pedigree
- From:
Journal of Peking University(Health Sciences)
2020;52(3):432-437
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To estimate the univariate heritability of resting heart rate and common chronic disease such as hypertension, diabetes, and dyslipidemia based on extended pedigrees in Fujian Tulou area and to explore bivariate heritability to test for the genetic correlation between resting heart rate and other relative phenotypes.
METHODS:The study was conducted in Tulou area of Nanjing County, Fujian Province from August 2015 to December 2017. The participants were residents with Zhang surname and their relatives from Taxia Village, Qujiang Village, and Nanou Village or residents with Chen surname and their relatives from Caoban Village, Tumei Village, and Beiling Village. The baseline survey recruited 1 563 family members from 452 extended pedigrees. The pedigree reconstruction was based on the family information registration and the genealogy booklet. Univariate and bivariate heritability was estimated using variance component models for continuous variables, and susceptibility-threshold model for binary variables.
RESULTS:The pedigree reconstruction identified 1 seven-generation pedigree, 2 five-generation pedigrees, 23 four-generation pedigrees, 186 three-generation pedigrees, and 240 two-generation pedigrees. The mean age of the participants was 57.2 years and the males accounted for 39.4%. The prevalence of hypertension, diabetes, dyslipidemia in this population was 49.2%, 10.0%, and 45.2%, respectively. The univariate heritability estimation of resting heart rate, hypertension, and dyslipidemia was 0.263 (95%CI: 0.120－0.407), 0.404 (95%CI: 0.135－0.673), and 0.799 (95%CI: 0.590－1), respectively. The heritability of systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was 0.379, 0.306, 0.393, 0.452, 0.568, 0.852, and 0.387, respectively. In bivariate analysis, there were phenotypic correlations between resting heart rate with hypertension, diabetes, diastolic blood pressure, fasting glucose, and triglyceride. After taking resting heart rate into account, there were strong genetic correlations between resting heart rate with fasting glucose (genetic correlation 0.485, 95%CI: 0.120－1, P<0.05) and diabetes (genetic correlation 0.795, 95%CI: 0.181－0.788, P<0.05).
CONCLUSION:Resting heart rate was a heritable trait and correlated with several common chronic diseases and related traits. There was strong genetic correlation between resting heart rate with fasting glucose and diabetes, suggesting that they may share common genetic risk factors.
