A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China.
- Author:
Xiao Ying ZHANG
1
;
Jia Jing PENG
1
;
Chuan Hui LIU
2
;
Xiao Yan CAI
3
;
Jiang Lin ZHANG
4
;
Yi Fang MEI
5
;
Hong Tao JIN
6
;
Xiao Fei WANG
7
;
Hong MO
8
;
Zhan Guo LI
1
Author Information
1. Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.
2. Department of Rheumatology and Immunology, Zhengzhou Orthopaedics Hospital, Zhengzhou 450052, China.
3. Department of Rheumatology and Immunology, Guangzhou First People's Hospital, Guangzhou 510180, China.
4. Department of Rheumatology and Immunology, Chinese PLA General Hospital, Beijing 100039, China.
5. Department of Rheumatology and Immunology, The First Hospital of Harbin Medical University, Harbin 150001, China.
6. Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
7. Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
8. Department of Rheumatology and Immunology, Nanning First People's Hospital, Nanning 530022, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
China;
Cross-Sectional Studies;
Female;
Humans;
Male;
Middle Aged;
Osteoarthritis, Hip/drug therapy*;
Osteoarthritis, Knee/drug therapy*;
Practice Patterns, Physicians'/statistics & numerical data*;
Retrospective Studies;
Surveys and Questionnaires
- From:
Journal of Peking University(Health Sciences)
2018;50(6):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical characteristics, the medicine application and to evaluate the disease activity in patients with osteoarthritis (OA) in China.
METHODS:This was a cross-sectional study. Totally 1 066 cases of OA from 40 hospitals in China from April to October 2017 were retrospectively enrolled. Demographic characteristics, clinical data, medicine application, and joint function were evaluated. All the data were analyzed by SPSS software 19.0. t test, Mann-Whitney U test and chi-square test were used for statistical analysis.
RESULTS:In the 1 066 cases, the male-to-female ratio was 1:3.6 and the average age was (61.9±11.0) years, with an age range from 36 to 94 years. The incidence of knee OA, hip OA, and hand OA were respectively 81.9% (873/1 066), 14.1% (150/1 066), and 36.3% (387/1 066). In the study, 242 (22.7%) cases had two kinds of joint areas involved and three joint areas were involved in 51 cases (4.8%), and 56.6% (603/1 066) of the patients used more than one kind of non-steroid anti-inflammatory drugs (NSAIDs) while 61.2% (652/1 066) used disease modifying osteoarthritis drugs (DMOADs), including glucosamine (37.5%, 400/1 066), chondroitin sulfate (2.0%, 21/1 066), diacetate (5.9%, 63/1 066), and the combination of these drugs (15.8%, 168/1 066). 8.6% (92/1 066) patients only took analgesics to relieve the pain, not using any kind of NSAIDs or DMOADs. And 232 patients (21.7%) had intra-articular injections, including 9.2% (98/1 066) sodium hyaluronate, 4.5%(48/1 066) glucocorticoid, and 8.1% (86/1 066) combination of the two drugs. The proportion of the patients taking topical drugs accounted for 26.5% (283/1 066) and physical therapy accounted for 15.8% (168/1 066). Compared with those who suffered from knee OA, the patients who suffered from hip OA had more severe disease assessment. Moreover, there were significant differences in pain (Z=-7.625, P<0.001), morning stiffness (Z=-6.229, P<0.001), and joint function (Z=-6.777, P<0.001) between the two groups of the patients who suffered from knee or hip OA with The Western Ontario and McMaster Universities (WOMAC) osteoarthritis index. Furthermore, patients with hip OA took more analgesics (χ2=24.838, P<0.001).
CONCLUSION:Oral NSAIDs and DMOADs are wildly used in patients with OA in China. However, the treatment of some patients still need to be improved. Patients with hip OA are more seriously ill and require aggressive treatment.
