Carotid plaque composition and volume evaluated by multi-detector computed tomography angiography.
- Author:
Jin Yong LI
1
;
Hong Liang SUN
2
;
Zhi Dong YE
1
;
Xue Qiang FAN
1
;
Peng LIU
1
Author Information
1. Department of Cardiovascular Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
2. Department of Radiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
- Publication Type:Journal Article
- MeSH:
Carotid Arteries;
Carotid Stenosis/diagnostic imaging*;
China;
Computed Tomography Angiography;
Humans;
Plaque, Atherosclerotic/diagnostic imaging*;
Retrospective Studies
- From:
Journal of Peking University(Health Sciences)
2018;50(5):833-839
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the differences of plaquecomposition and volume between symptomatic and asymptomatic patients with carotid artery stenosis by multi-detector computed tomography angiography (MDCTA).
METHODS:The consecutive patients with internal carotid artery stenosis≥70% diagnosed by digital subtraction angiography (DSA) were retrospectively analyzed from July 2011 to December 2015 in Peking University China-Japan Friendship School of Clinical Medicine. The symptomatic patients were defined as those who experienced nondisabling ischemic stroke or transient cerebralis chemic symptoms, including hemispheric events oramaurosis fugaxin the last 6 months. Otherwise, the patients were considered as a symptomatic. A total of 78 patients were enrolled in the study. Of these patients, there were 35 asymptomatic patients (44.9%) and 43 symptomatic patients (55.1%). All the patients received MDCTA before DSA. According to the plaque analysis of post processing work station, carotid plaques were divided into lipid-rich necrotic coreplaques (HU≤60), fibrous plaques (60 to 130 HU) and calcified plaques (HU≥130) through the different value sthreshold of HU. The plaque volume and proportion were all calculated. The differences between the two groups were compared by statistical methods.
RESULTS:The proportion of calcified plaques in asymptomatic patients was significantly higher than in symptomatic patients (t=2.760, P=0.007).And the proportion of LRNC plaqueswas lower than that in symptomatic patients (Z=2.009, P=0.044). There was statistical significance between the asymptomatic and symptomatic patients. Multivariate analysis showed that there was a positive correlation between the proportion of calcified plaques and asymptomatic carotid artery stenosis (OR=0.949; 95%CI: 0.915 to 0.985; P=0.005). The proportion of LRNC plaques showed a negative correlation with asymptomatic carotid artery stenosis (OR=1.068; 95%CI: 1.021 to 1.117; P=0.004). For the symptomatic patients, when the LRNC plaque proportion was greater than 30.3%, the specificity was 94.3%, and the sensitivity was 37.2%. There was no significant difference in plaque volume and fibrous plaque proportion in both groups.
CONCLUSION:Compared with symptomatic carotid plaques, the proportion of asymptomatic calcified plaques increased but the proportion of LRNC plaques decreased. Plaque LRNC 30.3% of the total volume may represent a clinically useful cutoff. For the patients with carotid artery stenosis, MDCTA may help noninvasively risk-stratify patients.
