Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Ability in Patients with Mild Cognitive Impairment after Ischemic Stroke

VernacularTitle:重复经颅磁刺激对脑梗死后轻度认知功能障碍的影响及安全性研究
Author: Yamei LI ; Li XU ; Yan YANG ; Jinyan TIAN ; Qian YU
Publication Type:Journal Article
Keywords: cerebral infarction, mild cognitive impairment, repetitive transcranial magnetic stimulation, event-related potential, P300
From: Chinese Journal of Rehabilitation Theory and Practice 2015;21(10):1128-1132
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive ability of patients after ischemic stroke. Methods 45 patients with mild cognitive impairment (MCI) after ischemic stroke were randomly assigned into control group (n=22) and observation group (n=23). Both groups received routine drugs and cognitive training. The observation group received rTMS over the left dorsolateral prefrontal cortex (DLPFC) (5 Hz, 80% motor threshold) in addition for 4 weeks. Results The score of Montreal Cognitive Assessment (MoCA), P300 latencies and amplitudes improved after treatment in both groups (P<0.001), and were better in the observation group than in the control group (P<0.05). The MoCA score was negatively related with P300 latency (r=-0.851, P<0.05). There was no severe adverse effect during the treatment. Conclusion rTMS could improve the cognitive ability of patients with MCI after stroke, with little side effect.