Association of rs17458312 Polymorphism of PSMA6 Gene with Cerebral Infarction

VernacularTitle:PSMA6基因rs17458312位点多态性与脑梗死的相关性研究
Author: Xiyao ZHAO ; Fangmei HE
Publication Type:Journal Article
Keywords: PSMA6 gene, single nucleotide polymorphism, cerebral infarction
From: Chinese Journal of Rehabilitation Theory and Practice 2015;21(9):1091-1094
CountryChina
Language:Chinese
Abstract: Objective To evaluate the association between rs17458312 (-1520C/T) polymorphism of PSMA6 gene and cerebral infarction in Chinese Han population. Methods 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were selected in the study. The single nucleotide polymorphism of rs17458312 of PSMA6 gene was identified with the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotypes and allele frequencies distributed in cerebral infarction patients and healthy controls were analyzed. Results The frequencies of CC, CT, TT genotypes and the C allele all revealed no significant difference between the case group and the control group (P>0.05). After stratified by genders, the difference among all genetypes and alleles weren't significant between subgroup (P>0.05). Conclusion The rs17458312 of PSMA6 gene might not be associated with the cerebral infarction.