Association between glycolysis and mitochondrial dysfunction and its potential value in liver diseases
10.3969/j.issn.1001-5256.2022.08.042
- VernacularTitle:糖酵解与线粒体功能障碍的关系及其在肝脏疾病中的潜在价值
- Author:
Gengjie YAN
1
;
Yong LIN
1
;
Huiji SU
1
;
Hanxiao CHEN
1
;
Shaoqun BAN
1
;
Ailing WEI
1
,
2
;
Dewen MAO
2
;
Fuli LONG
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2. Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Reviews
- Keywords:
Liver Diseases;
Glycolysis;
Mitochondria
- From:
Journal of Clinical Hepatology
2022;38(8):1931-1936
- CountryChina
- Language:Chinese
-
Abstract:
Glycolysis plays an important role in the development and progression of liver diseases and shows varying degrees of enhancement in different liver diseases, and it is closely associated with mitochondrial dysfunction (oxidative phosphorylation deficiency and reactive oxygen species production), which helps to fill energy production deficiency caused by impaired oxidative phosphorylation. Therefore, it might be possible to search for potential new therapies for liver diseases through targeted regulation of the key factors in aerobic glycolysis, such as hexokinase 2, pyruvate kinase M2, and other regulatory pathways. From the perspective of the association between glycolysis and liver diseases, this article elaborates on the therapeutic significance and potential value of glycolysis in liver diseases, in order to provide new ideas for the diagnosis and treatment of liver diseases.
