Tryptophan and tumor immunity
10.16438/j.0513-4870.2022-0528
- VernacularTitle:色氨酸与肿瘤免疫
- Author:
Chi ZHANG
;
Shi-jia YAN
;
Guo-hui WAN
- Publication Type:Research Article
- Keywords:
tumor;
tryptophan metabolism;
regulation of gene expression;
intestinal flora;
IDO1/TDO2-KYN-AhR;
inhibitor
- From:
Acta Pharmaceutica Sinica
2022;57(9):2580-2589
- CountryChina
- Language:Chinese
-
Abstract:
As an essential amino acid, tryptophan (Trp) has various physiological functions and is of great significance in the metabolic process of tumors. In the human body, tryptophan is mainly transformed through kynurenine metabolic pathway, which not only promotes the inherent malignant properties of tumor cells, but also leads to immune-suppressive tumor microenvironment. Changes in tryptophan metabolism often occur in tumors, accompanied by abnormal gene expression of tryptophan-related enzymes, among which indoleamine 2,3-bioxygenase (IDO)-related gene expression and tryptophan 2,3-dioxygenase (TDO)-related gene changes are the most significant. A large number of clinical trials on IDO inhibitors, TDO inhibitors and combination therapy have been carried out. This paper reviewed the tryptophan metabolic pathway, regulation of IDO (TDO), kynurenine (KYN) and other related genes in tumor cells, and outlined the development of therapeutic schedule targeting tryptophan-related genes. The new progress provides new ideas for the further exploration of tumor treatment options.
