Research progresses on NLRP3 inflammasomes-induced anti-tumor immunity
10.16438/j.0513-4870.2022-0520
- VernacularTitle:NLRP3炎性小体与抗肿瘤免疫作用研究进展
- Author:
Cui-cui SUN
;
Jing-wen DONG
;
Ze-an KUANG
;
Ming-xiao YIN
;
Xiao-jia LIU
;
Hong-bin DENG
- Publication Type:Research Article
- Keywords:
NOD-like receptor protein 3;
inflammasome;
interleukin-1β;
pyroptosis;
endritic cell;
anti-tumor immunity
- From:
Acta Pharmaceutica Sinica
2022;57(9):2612-2621
- CountryChina
- Language:Chinese
-
Abstract:
More and more studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome has become the regulatory factor of inflammatory response and protective immunity, and the assembly and activation of NLRP3 inflammasomes are closely related to the anti-tumor immunity effect. Depending on the cell type and stimuli, activation of the NLRP3 inflammasome can induce immune cells to become polarized, hyperactive, or pyroptotic, releasing interleukin (IL)-1β and IL-18, which leads to cascade immune or inflammatory responses, and its role in tumor immunity has received extensive attention. Here, we review the mechanisms of the NLRP3 inflammasome enhancing CD8+ T cells-mediated anti-tumor immunity by inducing the pyroptosis of tumor cell, the pyroptosis or hyperactive state of dendritic cells (DCs), and the pyroptosis or polarization of the macrophages. Different anti-tumor immune roles of NLRP3 inflammasome activation in tumor cells and immune cells provide new directions for future research and may influence the development of next-generation immunotherapy.
