A new pair of coumarin-like enantiomeric isomers from Gerbera piloselloides
10.16438/j.0513-4870.2022-0407
- VernacularTitle:毛大丁草中一对新的香豆素类对映异构体
- Author:
Ha GAO
1
,
2
;
Chen-xu ZHAO
1
,
2
;
Xin-yao LUO
3
,
4
;
Jing-rong LI
3
,
5
;
Yan-jun SUN
1
;
Tao ZHANG
3
;
Zhong-mei ZOU
1
,
2
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100193, China
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100193, China
4. Pharmacy Faculty Hubei University of Chinese Medicine, Hubei Provincial Key Laboratory of Chinese Medicine Resource, Wuhan 430065, China
5. Guizhou Medical University, Guizhou 550000, China
- Publication Type:Research Article
- Keywords:
compositae;
italic>Gerbera piloselloides;
X-ray;
enantiomer;
survival rate
- From:
Acta Pharmaceutica Sinica
2022;57(9):2774-2779
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated from the 95% ethanol extract of the whole plant of Gerbera piloselloides by silica gel column chromatography, MCI column chromatography and semi-preparative HPLC methods. Their structures were identified on the basis of physicochemical properties, spectral data (UV, IR, MS and NMR), circular dichroism (CD) spectra and single crystal X-ray diffraction analysis as 3′R-gerpilosecoumarin A (1a), 3′S-gerpilosecoumarin A (1b), gymnastone (2), gerberinside (3), divaricataester C (4), luteolin (5), caffeic acid methyl ester (6), ethyl chlorogenate (7), 6-(β-D-glucopyranosyloxy)-7-methoxy-5-benzoranpropanoic acid methyl ester (8) and glucozaluzanin C (9). Among them, new compounds 1a and 1b were new compounds and optical enantiomers, which were obtained by chiral resolution, and their absolute configurations were determined by quantum chemical calculation ECD. Compounds 1 and 1a/1b significantly increased the survival of IEC-6 in rat small intestinal crypt epithelial cells after LPS injury.
