Research progress of metabolic flux analysis technology in glucose metabolism pathway research
10.16438/j.0513-4870.2022-0311
- VernacularTitle:代谢流分析技术在葡萄糖代谢通路研究中的进展
- Author:
Yun-hao ZHAO
1
;
Ting LINGHU
1
;
Wen-ze WU
1
;
Xian-xian WANG
1
;
Yu-mei HAN
2
;
Xue-mei QIN
1
;
Jun-sheng TIAN
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. School of Physical Education, Shanxi University, Taiyuan 030006, China
- Publication Type:Research Article
- Keywords:
metabolic flux analysis;
stable isotope tracer metabolomics;
glucose metabolism;
metabolic pathway
- From:
Acta Pharmaceutica Sinica
2022;57(9):2731-2737
- CountryChina
- Language:Chinese
-
Abstract:
With the wide application of stable isotope tracer metabolomics technology, its comprehensive analysis and in-depth mining of data are particularly important, and metabolic flux analysis is one of the main technical means, especially in the study of glucose metabolism. Metabolic flux analysis technology combines isotope tracing with mathematical models to deduce and calculate the metabolic flux between metabolites. The metabolic flux provides more information for research and reflects a dynamic metabolic process more clearly and specifically. This paper reviews the basic process, precautions, and application examples of metabolic flux analysis in glucose metabolism research, and provides a reference for the application of metabolic flux analysis based on stable isotope tracer metabolomics in glucose metabolism research.
