Application progress of ischemic preconditioning in ischemia-reperfusion injury of renal allografts
10.3969/j.issn.1674-7445.2022.05.016
- VernacularTitle:缺血预处理在移植肾缺血-再灌注损伤中的应用进展
- Author:
Lang SHI
1
;
Jiefu ZHU
;
Xiongfei WU
Author Information
1. Department of Nephrology, People's Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Ischemic preconditioning;
Ischemia-reperfusion injury;
Kidney transplantation;
Acute kidney injury;
Endothelial cell homing;
Nitric oxide;
Mitophagy;
MicroRNA
- From:
Organ Transplantation
2022;13(5):653-
- CountryChina
- Language:Chinese
-
Abstract:
Kidney transplantation is more efficacious compared with other organ transplantations. Nevertheless, postoperative complications, such as renal ischemia-reperfusion injury (IRI), severely affect the survival rate and quality of life of recipients. How to mitigate the IRI of renal allografts has become one of the key topics in the field of kidney transplantation. At present, ischemic preconditioning enables renal allografts to adapt to ischemia, which is one of the effective methods to prevent the progression of IRI. However, the underlying mechanism remains elusive. In this article, the application of ischemic preconditioning in IRI, the regulation mechanism of ischemic preconditioning on the IRI of renal allografts at the cellular level and intracellular signaling pathway, and clinical application value and prospect of ischemic preconditioning were reviewed, aiming to provide reference for alleviating the IRI of renal allografts, enhancing the survival rate of the recipients and renal allografts and improving the quality of life of recipients.
