Research progress on the role of STING signal pathway in ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2022.05.007
- VernacularTitle:STING信号通路在缺血-再灌注损伤中的作用研究进展
- Author:
Haoran HU
1
;
Jian XU
;
Haoming ZHOU
Author Information
1. Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
Ischemia-reperfusion injury;
Stimulator of interferon genes;
Inflammation;
Innate immunity;
Macrophage;
Pattern recognition receptor;
Autophagy;
Cell death
- From:
Organ Transplantation
2022;13(5):591-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury (IRI) is a pathophysiological process, which widely exists in organ transplantation and surgery. IRI is mainly manifested with hypoxia injury of organs or tissues during the ischemia period, which could be further aggravated after reperfusion. Ischemia-reperfusion induces tissue cell injury, releases damage-associated molecular pattern and further activates multiple immune cells via pattern recognition receptor, leading to aseptic inflammation and aggravating tissue injury. Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), as a critical member of pattern recognition receptor, could activate the stimulator of interferon genes (STING) signal pathway and play an important regulatory role in innate immune response. At present, increasing evidences have shown that cGAS-STING signal pathway plays a significant role in organ IRI. In this article, STING signaling pathway, its role and mechanism in IRI of different organs were reviewed, aiming to provide novel ideas for clinical interventions.
