Recurrence of IgA nephropathy after kidney transplantation
10.3969/j.issn.1674-7445.2022.05.006
- VernacularTitle:肾移植术后IgA肾病复发
- Author:
Yinsheng ZHANG
1
;
Xingtong PENG
;
Tingkai YANG
;
Jiali XING
;
Jin WEN
;
Zhigang JI
Author Information
1. Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
- Publication Type:Research Article
- Keywords:
Kidney transplantation;
IgA nephropathy (IgAN);
End-stage renal disease;
Recurrence;
Galactose-deficient IgA1 (Gd-IgA1);
Proteinuria;
Glucocorticoid;
Immunosuppressant
- From:
Organ Transplantation
2022;13(5):583-
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy (IgAN) is one of the common primary glomerulonephritis, which is also an important risk factor for end-stage renal disease. Kidney transplantation is the optimal treatment for end-stage renal disease induced by IgAN, whereas there is still a risk of recurrence of IgAN after kidney transplantation. At present, research progress upon IgAN recurrence after kidney transplantation is relatively lacking. The pathogenesis of IgAN recurrence remains elusive, and its pathological manifestations are not specific. The diagnosis of IgAN recurrence still depends on renal biopsy. Besides, no effective prevention and treatment are available for recurrent IgAN. In this article, research progress on IgAN recurrence after kidney transplantation was illustrated from the perspectives of pathogenesis, diagnosis, risk factors and treatment, aiming to provide reference for clinical prevention and treatment of IgAN recurrence after kidney transplantation and improve clinical prognosis of kidney transplant recipients.
