Association of 5-HTR1A gene C- 1019G polymorphism with antidepressant efficacy ：a meta-analysis
- VernacularTitle:5-HTR1A基因C-1019G多态性与抗抑郁药物疗效相关性的Meta分析
- Author:
Wenwen CAI
1
;
Xiuli SUN
2
;
Jian CUI
3
;
Xiuying LI
1
;
Silan GUI
1
;
Junqing ZHANG
1
Author Information
1. Dept. of Pharmacy，Shangdong Daizhuang Hospital，Shandong Jining 272000，China
2. Dept. Four of Psychiatry，Shangdong Daizhuang Hospital，Shandong Jining 272000，China
3. Dept. One of Psychiatry，Shangdong Daizhuang Hospital，Shandong Jining 272000，China
- Publication Type:Journal Article
- Keywords:
antidepressant;
5-HTR1A gene;
C-1019G polymorphism;
efficacy;
meta-analysis
- From:
China Pharmacy
2022;33(17):2142-2146
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the correlation between 5-HTR1A gene C- 1019G polymorphism and the efficacy of antidepressants. METHODS PubMed，Embase，Cochrane Library ，CNKI，Wanfang database ，CBM and VIP database were searched for domestic and foreign literatures on the correlation between 5-HTR1A gene C- 1019G polymorphism and antidepressant efficacy. The retrieval time limit was from the inception to February 2022. According to different outcome measures of drug response，Stata 14.0 and RevMan 5.4 software were used for meta-analysis of efficacy group and remission group ，respectively. RESULTS A total of 18 literature were included. The combined results showed that among recessive gene model in valid group ， the correlation of 5-HTR1A gene C- 1019G polymorphism with the efficacy of antidepressants had statistically significance in Asian population（GG vs. CG+CC ，OR＝0.751，95％CI＝0.585-0.964，P＝0.024）. There was statistical significance in the correlation of 5-HTR1A gene C- 1019G polymorphism and the efficacy of antidepressants in China （GG vs. CG+CC ，OR＝0.677，95％CI＝ 0.508-0.901，P＝0.007）. There was no statistical significance in the correlation of 5-HTR1A gene C- 1019G polymorphism and the efficacy of antidepressants in remission group （P＞0.05）. CONCLUSIONS In the effective group ，5-HTR1A gene C- 1019G polymorphism is correlated with the efficacy of antidepressants in the Asian population and the Chinese population ；while in the remission group ，it is not proved that this polymorphism is correlated with the efficacy of antidepressants.
