Data mining of adverse drug reaction of iodine contrast media based on spontaneous reporting system
- VernacularTitle:基于自发呈报系统的碘对比剂不良反应数据挖掘
- Author:
Biyu TANG
1
;
Jianru WU
1
;
Fenfang WEI
1
;
Wenyu WU
1
Author Information
1. Shenzhen Institute of Pharmacovigilance and Risk Management，Guangdong Shenzhen 518024，China
- Publication Type:Journal Article
- Keywords:
Iodine contrast media;
signal mining;
spontaneous reporting system;
adverse reaction;
signal detection
- From:
China Pharmacy
2022;33(17):2129-2132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To mine the risk sig nals o f iodine contrast media from spontaneous reporting system. METHODS Reporting odds ratio ，proportional reporting ratio ，Medicines and Healthcare Products Regulatory Agency and Bayesian confidence propagation neural network were used to mine risk signals of 5 iodine contrast media （iopamidol，iohexol，iopromide，ioversol， iodixanol）. RESULTS 1 164（2 446 case times ）adverse drug reaction of iodine contrast media were included ，a total of 14 risk signals involving systems/organs such as respiratory system （3，2，4，3，2 for the above 5 iodine contrast media ）and immune system and 32 specific adverse drug reaction signals including anaphylactic shock ，rash and flushing （11，7，7，3，4 for the above 5 iodine contrast media ）were found in 5 iodine contrast media. CONCLUSIONS The risk signals of 5 iodine contrast media verify that there is a certain correlation between these drugs and above adverse drug reactions. It is suggested that before using iodine contrast media in clinic ，it is necessary to pay attention to whether the patient has a history of tumor and combined medication ，evaluate the patient’s renal function ，and give preventive measures such as hydration in advance. When using iodine contrast media ，it is necessary to pay attention to the temperature ，dose and injection rate. And medical staff need to follow up the patient ’s situation in time after using iodine contrast media to avoiding the impact of delayed adverse reactions.
