A cohort study on the association between resting heart rate and the risk of new-onset heart failure.
10.3760/cma.j.cn112148-20190703-00374
- Author:
Hong Min LIU
1
;
Shuo Hua CHEN
2
;
Yun Tao WU
1
;
Xiao Ming ZHENG
1
;
Zhe HUANG
1
;
Xing LIU
3
;
Xiao Hong ZHAO
1
;
Hai Yan ZHAO
1
;
Chun Yu RUAN
1
;
Chang Hao ZU
1
;
Yang Yang WANG
4
;
Shou Ling WU
1
Author Information
1. Department of Cardiology, Kailuan General Hosipital, Tangshan 063000, China.
2. Employee Health Protection Center, Kailuan General Hosipital, Tangshan 063000, China.
3. Department of Gastroenterology, Kailuan General Hosipital, Tangshan 063000, China.
4. Department of Gynaecology and Obstetrics, Kailuan General Hosipital, Tangshan 063000, China.
- Publication Type:Journal Article
- Keywords:
Heart failure;
Resting heart rate
- MeSH:
Adult;
Blood Pressure;
Cohort Studies;
Female;
Heart Failure;
Heart Rate;
Humans;
Male;
Middle Aged;
Prospective Studies;
Risk Factors
- From:
Chinese Journal of Cardiology
2020;48(5):413-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prospectively explore the relationship between resting heart rate (RHR) and risk of new-onset heart failure. Methods: It was a prospective cohort study. People who attended the physical examination of Kailuan Group Company in 2006 and with complete electrocardiography (ECG) recordings were eligible for this study. A total of 88 879 participants aged 18 years old or more who were free of arrhythmia, a prior history of heart failure and were not treated with β-blocker were included. Participants were divided into 5 groups according to the quintiles of RHR at baseline (Q(1) group, 40-60 beats/minutes (n=18 168) ; Q(2) group, 67-70 beats/minutes (n=18 970) ; Q(3) group, 71-74 beats/minutes (n=13 583) ; Q(4) group, 75-80 beats/minutes (n=22 739) ; and Q(5) group,>80 beats/minutes (n=15 419) ) .The general clinical data and laboratory test results were collected. The outcome was the first occurrence of heart failure at the end of follow-up (December 31, 2016) .We used Cox regression model to examine the association between RHR and the risk of new-onset heart failure. Hazard ratio (HR) with 95% confidence intervals (CI) were calculated using Cox regression modeling. Results: Among the included patients 68 411 participants were male, mean age was (51.0±12.3) years old, and RHR was (74±10) beats/minutes. Statistically significant differences among the RHR quintiles were found for the following variables: age, gender, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting blood glucose, body mass index, the level of high-sensitivity C-reactive protein, education status, physical activity, smoking status, drinking status, history of diabetes, history of hypertension and history of use antihypertensive drugs (all P<0.01) . Higher RHR was linked with higher prevalence of diabetes, hypertension history, and higher systolic blood pressure, diastolic blood pressure and FBG levels (all P<0.01). After a mean follow-up of 9.5 years, the incidence of new-onset heart failure in Q(1), Q(2), Q(3), Q(4) and Q(5) groups was 1.60%(290/18 168), 1.36%(258/18 970), 1.80%(245/13 583), 1.76%(400/22 739) and 2.35%(362/15 419),respectively (P<0.01) . The person-year incidence of heart failure in Q(1), Q(2), Q(3), Q(4) and Q(5) groups was 1.7, 1.5, 1.9, 1.9 and 2.6 per 1 000 person-years respectively. Compared with the Q(2) group, multivariate analysis with adjustment for major traditional cardiovascular risk factors showed that HRs of Q(3),Q(4),and Q(5) group were 1.23 (95%CI 1.03-1.48, P<0.05) , 1.19 (95%CI 1.01-1.41, P<0.05) , 1.39 (95%CI 1.18-1.65, P<0.01) , respectively. In the absence of hypertension, diabetes, smoking and acute myocardial infarction, the Cox regression model showed that compared with Q(2) group, the HR of new-onset heart failure in Q(5) group was 1.58 (95%CI 1.02-2.45, P<0.05) . Conclusion: Increased RHR is associated with increased risk of new-onset heart failure in this cohort.
