Clinical and Biochemical Profiles according to Homeostasis Model Assessment-insulin Resistance (HOMA-IR) in Korean Women with Polycystic Ovary Syndrome.
10.6118/jmm.2014.20.3.104
- Author:
Da Eun LEE
1
;
Soo Yeon PARK
;
So Yun PARK
;
Sa Ra LEE
;
Hye Won CHUNG
;
Kyungah JEONG
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea. ogjeong@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Cardiovascular diseases;
Homeostasis;
Insulin resistance;
Polycystic ovary syndrome;
Risk factors
- MeSH:
Apoproteins;
Body Mass Index;
Body Weight;
C-Reactive Protein;
Cardiovascular Diseases;
Cholesterol;
Embryology;
Female;
Glucose;
Hematologic Tests;
Homeostasis*;
Humans;
Insulin Resistance;
Lipid Accumulation Product;
Lipoproteins;
Metabolome;
Polycystic Ovary Syndrome*;
Reproduction;
Risk Factors;
Sex Hormone-Binding Globulin;
Testosterone;
Triglycerides;
Ultrasonography;
Waist-Hip Ratio
- From:Journal of Menopausal Medicine
2014;20(3):104-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. METHODS: In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormones, glucose metabolic and lipid profiles, and transvaginal or transrectal ultrasonogram were carried out. HOMA-IR was then calculated and compared with the clinical and biochemical profiles related to PCOS. The patients were divided into 4 groups by quartiles of HOMA-IR. RESULTS: The mean level of HOMA-IR was 2.18 +/- 1.73. Among the four groups separated according to HOMA-IR, body weight, body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, lipid accumulation product (LAP) index, high-sensitivity C-reactive protein (hs-CRP), Apoprotein B, free testosterone, and sex hormone binding globulin (SHBG) were found to be significantly different. TG, LAP index, glucose metabolic profiles, and hs-CRP were positively correlated with HOMA-IR after adjustment for BMI. CONCLUSION: Our results suggest that the clinical and biochemical profiles which are applicable as cardiovascular risk factors are highly correlated with HOMA-IR in Korean women with PCOS.
