Value of absolute quantification of myocardial perfusion by PET in detecting coronary microvascular disease in patients with non-obstructive coronaries
10.3760/cma.j.cn112148-20191024-00652-1
- VernacularTitle:PET心肌血流绝对定量评估冠状动脉微血管疾病的临床研究
- Author:
Ping WU
1
;
Xiaoshan GUO
;
Xi ZHANG
;
Zhifang WU
;
Ruonan WANG
;
Li LI
;
Meng LIANG
;
Hongliang WANG
;
Min YAN
;
Zhixing QIN
;
Pengliang CHENG
;
Chunrong JIN
;
Minfu YANG
;
Yuetao WANG
;
Sijin LI
Author Information
1. 山西医科大学第一医院核医学科 分子影像山西省重点实验室，太原 030001
- Keywords:
Positron-emission tomography;
Coronary artery disease;
Coronary flow reserve;
Microcirculation
- From:
Chinese Journal of Cardiology
2020;48(3):205-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the incidence of coronary microvascular disease (CMVD) between patients with non-obstructive and obstructive coronary arteries.Methods:We retrospectively analyzed 97 patients with angina pectoris, who underwent the absolute quantitative PET examination of myocardial perfusion and coronary anatomy examination within 90 days. All patients were divided into two groups: non-obstructive group (72 cases, no stenosis ≥50% in all three coronary arteries) and obstructive group (25 cases, at least one coronary stenosis ≥50%; and at least one coronary stenosis<50%). Quantitative parameters derived from PET including rest myocardial blood flow (RMBF), stress myocardial blood flow (SMBF), coronary flow reserve (CFR) and cardiovascular risk factors were compared between the two groups. CMVD was defined as CFR<2.90 and SMBF <2.17 ml·min -1·g -1. Results:Incidence of CMVD was significant higher in the non-obstructive coronary arteries of the obstructive group than in the non-obstructive coronary arteries of non-obstructive group (47.1% (16/34) vs. 25.5% (55/216), χ 2=6.738, P=0.009) while incidence of CMVD was similar between non-obstructive and obstructive patients ((44% (11/25) vs. 33.3% (24/72), χ 2=0.915, P=0.339). RMBF ((0.83±0.14) ml·min -1·g -1 vs. (0.82±0.17) ml·min -1·g -1), SMBF ((2.13±0.60) ml·min -1·g -1 vs. (1.91±0.50) ml·min -1·g -1) and CFR (2.59±0.66 vs. 2.36±0.47) were similar between the two groups (all P>0.05). Conclusions:CMVD can occur in non-obstructive coronary arteries in both patients with non-occlusive coronary arteries and patients with obstructive coronary arteries. Prevalence of CMVD is significantly higher in patients with obstructive coronary arteries than in patients with non-obstructive coronary arteries. The CMVD severity is similar between the two groups.
