Research advances on the characteristics of fibroblast in keloid.
10.3760/cma.j.cn501120-20210510-00176
- VernacularTitle:瘢痕疙瘩中的成纤维细胞特性研究进展
- Author:
Yun Zhang WANG
1
;
Chen SU
2
;
Si Qi FU
3
;
Li Qiang LIU
1
Author Information
1. Department Nine of Plastic Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences, Beijing 100144, China.
2. Emergency Department, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China.
3. Department of Dermatology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Fibroblasts/metabolism*;
Humans;
Keloid/pathology*
- From:
Chinese Journal of Burns
2022;38(6):590-594
- CountryChina
- Language:Chinese
-
Abstract:
In re-cent 20 years, the development of cell biology technology has promoted the research of keloid. Keloid fibroblasts (KFbs) are the main effector cells in keloid, which are closely related to the occurrence and development of keloid. It is significantly different in terms of biological characteristics and gene expression between KFbs and normal fibroblasts. This articles reviews the characteristics of KFbs from multiple perspectives, describing its biological character- istics in details including microstructures, metabolic character- istics, and proliferation properties, and introducing the main characteristics of heterogeneity and genomics of KFbs. The further research on KFbs will help to elucidate the pathogenesis of keloids and provide valuable strategies for the prevention and treatment of keloids.
