Clinical characteristics and long-term follow-up results of radiofrequency ablation for the treatment of ventricular tachycardia in patients with arrhythmogenic left ventricular cardiomyopathy.
10.3760/cma.j.cn112148-20210927-00832
- Author:
Zhe WANG
1
;
Lin Sheng SHI
2
;
Hai Lei LIU
1
;
Zi Dun WANG
1
;
Xiao Hong JIANG
1
;
Hong Wu CHEN
1
;
Gang YANG
1
;
Kai GU
1
;
Wei Zhu JU
1
;
Ming Long CHEN
1
Author Information
1. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210000 China.
2. Department of Cardiology, Second Affiliated Hospital of Nantong University, Nantong 226001, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Cardiomyopathies;
Catheter Ablation;
Cross-Sectional Studies;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Pericardium/surgery*;
Recurrence;
Retrospective Studies;
Stroke Volume;
Tachycardia, Ventricular/surgery*;
Treatment Outcome;
Ventricular Function, Left
- From:
Chinese Journal of Cardiology
2022;50(6):549-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the acute and long-term outcome of catheter ablation for the treatment of ventricular tachycardia (VT) in patients with arrhythmogenic left ventricular cardiomyopathy (ALVC). Methods: This retrospective, cross-sectional study enrolled ALVC patients undergoing radiofrequency ablation for the treatment of VT at the First Affiliated Hospital of Nanjing Medical University from January 2011 to December 2018 and collected their clinical characteristics and intraoperative electrophysiological examination. Patients were followed up every 6 months after radiofrequency ablation until August 2021. Echocardiographic results and VT recurrence post radiofrequency ablation were analysed. Results: Totally 12 patients were enrolled (mean age: (42±15) years, 11 males(11/12)). The mean of left ventricular end diastolic diameter (LVDd) and left ventricular ejection fraction (LVEF) were (51±5)mm and (65±5)%, respectively. Twelve VTs were induced in 10 patients during the electrophysiological study, and the mean tachycardia cycle length was (293±65) ms. Three-dimensional substrate mapping revealed the diseased area at endocardial site in one patient, at epicardial sites in the other 11 patients (involved endocardial sites in 2 cases) with the basal part near the mitral annulus being the predilection for the substrate (10/11). After the catheter ablation at the endocardial and epicardial sites respectively, the complete procedure endpoint was achieved in all patients (VT cannot be induced post ablation). The median follow-up time was 65 (25, 123) months. One patient was lost to follow-up, and the other 11 patients survived without VT. No significant cardiac function deterioration was detected by the echocardiographic examination ((51±5)mm vs. (52±5)mm, P>0.05 for LVDd, (65±5)% vs. (60±6)%, P>0.05 for LVEF) at the end of follow-up. Conclusion: After radiofrequency ablation, the complete procedure endpoint is achieved in ALVC patients, and the catheter ablation provides long-term ventricular tachycardia control during the long-term follow-up.
