Spray Drying in Research of Traditional Chinese Medicine Powders： A Review
10.13422/j.cnki.syfjx.20211954
- VernacularTitle:喷雾干燥在中药粉体研究中的应用进展
- Author:
Shengyun DAI
1
;
Maorui YANG
2
;
Wenjing LI
2
;
Jian ZHENG
1
;
Bing XU
2
;
Yanjiang QIAO
2
Author Information
1. National Institutes for Food and Drug Control，Beijing 102629，China
2. School of Chinese Materia Medica，Beijing University of Chinese Medicine，Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine， Engineering Research Center of Key Technologies for Chinese Medicine Production and New Drug Development，Ministry of Education，Beijing 102488，China
- Publication Type:Review
- Keywords:
spray drying;
quality by design （QbD）;
physical characterization;
powder modification;
pharmaceutical excipients;
computational fluid dynamics （CFD）;
unification of medicines and excipients
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(14):200-208
- CountryChina
- Language:Chinese
-
Abstract:
After more than 100 years of development， spray drying technology has become more mature and widely used， and it is of great importance in the field of traditional Chinese medicine （TCM）. TCM powders prepared by spray drying is the raw material of dispensing granules， and the powder properties have an important influence on subsequent molding process and product quality. As a new form of TCM， dispensing granules have been included in the management category of TCM decoction pieces， indicating a broader application market， and a consensus has also been reached on the importance of TCM powder research. Based on this， the author summarized the application progress of spray drying in the study of TCM powders， including the factors affecting spray drying process， such as liquid properties， process parameters and equipment factors， as well as the application of computational fluid dynamics （CFD） and thermodynamic model in spray drying process simulation. Moreover， some commonly used pharmaceutical excipients for the modification of TCM powders were also introduced such as maltodextrin， microcrystalline cellulose and povidone. In addition， spray drying technology can also be used as a preparation technology for new drug delivery systems such as microcapsules and solid dispersions. Through the summary of this paper， the author suggests that the future research direction of spray drying of TCM can be carried out from the aspects of application rule of the coprocessing auxiliary materials based on the "unification of medicines and excipients"， the "structure-property" relationship of spray-dried powders and the application of computer simulation and design， so as to further enrich the application of spray drying in the field of TCM powders.
