Effect and Mechanism of Chinese Medicine Combined with Bone Marrow Mesenchymal Stem Cells in Treatment of Ischemic Stroke： A Review
10.13422/j.cnki.syfjx.20221340
- VernacularTitle:中药联合骨髓间充质干细胞治疗缺血性脑卒中作用及机制研究进展
- Author:
Xiaolong PAN
1
;
Shibiao SUN
1
;
Zhihui WEI
1
;
Feixiang LIU
1
;
Yunke ZHANG
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
bone marrow mesenchymal stem cells （BMSCs）;
ischemic stroke;
mechanism;
exosomes
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(15):248-258
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is one of the major diseases threatening human health， with ischemic stroke accounting for about 70%. Ischemic stroke is characterized by complex pathological mechanism and high incidence， mobility and mortality. At present， the effective clinical treatment measures for ischemic stroke are limited， and it is urgent to develop new and effective treatment measures to improve the prognosis of patients. In recent years， bone marrow mesenchymal stem cells （BMSCs） transplantation has shown great therapeutic potential for a variety of diseases， including ischemic stroke， and has become a new research hotspot. However， due to the low homing and survival rate of BMSCs in human body after transplantation， their clinical effect on ischemic stroke needs to be further improved. With the characteristics of multi-components， multi-channels and multi-targets， Chinese medicine displays desirable curative effect on ischemic stroke， which has been widely concerned. Both Chinese medicine and BMSCs transplantation have good overall brain protection， and their combined effect on ischemic stroke is significantly better than that of single application. The mechanisms include improving the transplantation efficiency of BMSCs， promoting angiogenesis， enhancing neuroplasticity， ameliorating neuroinflammation， enhancing neuroprotection， and regulating the blood-brain barrier and exosomes. The combination of Chinese medicine and modern cutting-edge cell therapy reflects the advantages of integrative medicine， providing a new model and idea for preventing and treating ischemic stroke and improving the efficacy of BMSCs transplantation.
