Chinese Medicine Regulates Atherosclerosis-related Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20221598
- VernacularTitle:中医药调控动脉粥样硬化相关信号通路的研究进展
- Author:
Manli ZHOU
1
;
Yanzhen ZHAO
1
;
Yunfeng YU
1
;
Yifan ZHANG
1
;
Yilei HU
1
;
Weixiong JIAN
1
Author Information
1. School of Traditional Chinese Medicine（TCM），Hunan University of Chinese Medicine， Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
Chinese medicine;
signaling pathway;
pathological mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(15):232-239
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerotic cardiovascular disease is a common disease with high incidence rate and mortality worldwide. Atherosclerosis is an important pathological basis for the formation of ischemic cardiovascular diseases such as cardiovascular disease， which is related to inflammation， oxidative stress， apoptosis， vascular endothelial damage， foam cell formation， platelet activation， and so on， involving mitogen-activated protein kinase （MAPK）， phosphoinositide 3-kinase/protein kinase B （PI3K/Akt）， cyclic adenosine monophosphate/protein kinase A （cAMP/PKA）， Ras homolog gene family member A （RhoA）/Rho-associated coiled-coil containing protein kinase （ROCK）， nuclear factor-kappa B （NF-κB）， and other signaling pathways. In the past few decades， high-intensity statins were mainly used to treat atherosclerosis by reducing blood lipid levels， which usually caused obvious side effects. Therefore， the development of safer and more effective drugs and treatment modes is the focus of research at this stage. In recent years， Chinese medicine has been playing an increasingly important role in the prevention and treatment of cardiovascular diseases in China. There are many studies on the mechanism of Chinese medicine in the prevention and treatment of atherosclerosis， and it is found that a variety of single Chinese medicine regulate the formation process of atherosclerosis by regulating targeted signal molecules. This paper reviewed the research results of related signaling pathways involved in the pathological formation of atherosclerosis and the mechanism of Chinese medicine in the prevention and treatment of cardiovascular diseases， thereby providing references for the clinical treatment of cardiovascular diseases.
