Biological Basis of Invigorating Qi and Activating Blood Cirulation in Regulating Neural Repair After Ischemic Stroke： A Review
10.13422/j.cnki.syfjx.20221543
- VernacularTitle:益气活血法在缺血性中风后神经修复中的生物学基础研究进展
- Author:
Xiaodi FAN
1
;
Yehao ZHANG
1
;
Jianxun LIU
1
Author Information
1. Beijing Key Laboratory of Pharmacology of Chinese Materia Medica， Institute of Basic Medical Sciences， Xiyuan Hospital of China Academy of Chinese Medical Sciences， Beijing 100091， China
- Publication Type:Review
- Keywords:
ischemic stroke;
neural repair;
syndrome of Qi deficiency and blood stasis;
invigorating qi and activating blood;
biological basis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(15):216-222
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is the leading cause of death and disability. Therefore， it is critical to develop the approaches for improving recovery and neural repair after stroke. Recovery after stroke involves complex interrelated systems of neural repair. The whole process of neural repair requires a series of coordinated interactions， such as response of neuronal cell body to traumatic stimuli， neural stem cell proliferation and migration， axoplasmic transport of signaling molecules， construction of cytoskeleton， and formation of axonal growth cone， to achieve regeneration and growth. As a potential new target for the treatment of neurologic defects， neural remodeling has important research significance in both the specific mechanism of neural repair and the clinical treatment of neurologic defects. After brain injury， single therapy is often ineffective due to the complex mechanism of internal repair， and thus comprehensive therapy becomes the development direction to improve the brain repair. Invigorating qi and promoting blood can promote nerve function remodeling after injury through neural protection， angiogenesis， neurogenesis， loop reconstruction， and cytokine regulation， playing a key role in nerve repair after stroke. Its mechanism is associated with autophagy， immunomodulation， and microRNA regulation， which fully embodies the multi-pathway， multi-target， and overall regulation characteristics of invigorating Qi and activating blood. Therefore， it is of theoretical and guiding significance to study the brain function rehabilitation after stroke by invigorating qi and activating blood.
