Modern Research of Nasal Preparations of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20220346
- VernacularTitle:中药鼻用制剂的现代研究进展
- Author:
Fangkun YU
1
;
Jiao CHEN
1
;
Linghui LI
1
;
Qian ZHANG
1
;
Zongping ZHU
1
;
Rui LI
1
;
Shuguang HOU
1
;
Wan LIAO
1
Author Information
1. National Key Laboratory of Specific Chinese Drug Resources in Southwest China，School of Pharmacy，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
- Publication Type:Journal Article
- Keywords:
nasal preparations;
nasal administration;
pharmaceutical excipients;
clinical trials;
new dosage forms;
traditional Chinese medicine （TCM）;
safety evaluation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(16):245-253
- CountryChina
- Language:Chinese
-
Abstract:
Nasal preparations have unique advantages in drug delivery and are widely used in the treatment of local and systemic diseases. Nasal administration of traditional Chinese medicine （TCM） has a long history in China. In recent years， nasal preparations of TCM have attracted wide attention. Based on the information about nasal preparations of TCM from the database of National Medical Products Administration （NMPA）， Yaozh.com and China National Knowledge Internet （CNKI） in the recent 30 years， the formulation， the listed products， commonly used TCM， pharmaceutical excipients， clinical application and safety research of modern nasal preparations of TCM were summarized and expounded. Focusing on many problems in the development of modern nasal preparations of TCM， such as inaccurate dosage of some products， incomplete quality standard system of pharmaceutical excipients， imperfect safety evaluation， lack of research and development of nasal drug delivery devices and so on， the possible solutions and prospects were put forward from the aspects of optimizing the extraction and separation process of TCM， the quality control and application method of pharmaceutical excipients， the development of new dosage forms， the safety evaluation of nasal administration of TCM， and the design and development of nasal administration devices. The aim is to provide ideas for the development of nasal preparations of TCM and provide scientific basis for its sustainable utilization.
