Clinical Efficacy of Zishui Bugan Decoction on Perimenopausal Insomnia Patients with Liver-kidney Deficiency
10.13422/j.cnki.syfjx.20221696
- VernacularTitle:滋水补肝汤治疗围绝经期肝肾亏虚型失眠的临床疗效
- Author:
Xiujuan MI
1
;
Junnan FANG
2
;
Xinyuan YU
1
;
Zhaoliang LUO
1
;
Jun TANG
1
;
Jing CHEN
1
Author Information
1. Chongqing Traditional Chinese Medicine（TCM）Hospital，Chongqing 400021，China
2. Zhangzhou TCM Hospital，Zhangzhou 363099，China
- Publication Type:Journal Article
- Keywords:
Zishui Bugan decoction;
insomnia;
perimenopause;
randomized controlled clinical trial;
Bugantang;
Liuwei Dihuangwan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(16):116-122
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy of Zishui Bugan decoction on perimenopausal insomnia of liver-kidney deficiency type and the safety. MethodA randomized， double-blind， placebo-controlled trial was designed. To be specific， 72 patients of perimenopausal insomnia with Liver-kidney deficiency were randomized into the treatment group and the control group at the ratio of 1∶1 and they were respectively treated with Zishui Bugan decoction and placebo for 3 weeks. The Pittsburgh sleep quality index （PSQI）， modified Kupperman index， traditional Chinese medicine （TCM） syndrome score， self-rating anxiety scale （SAS） score， and self-rating depression scale （SDS） score， were compared before and after treatment to determine the clinical efficacy， with adverse effects recorded. ResultThe total effective rate for insomnia was 85.3%（29/34） in treatment group and 17.6%（6/34） in control group（Z=-5.582，P<0.01）. After treatment， PSQI score， modified Kupperman index， TCM syndrome score， and SAS score were improved in both groups （P<0.05， P<0.01）， particularly the treatment group which showed significant difference from the control group （P<0.05，P<0.01）. The safety indicators were insignificantly different between two groups before and after treatment. No related adverse effects were reported in both groups during the treatment. ConclusionZishui Bugan decoction can improve the sleep quality and alleviate the menopausal symptoms， such as depression and anxiety， which shows ideal efficacy and safety for the perimenopausal insomnia with liver-kidney deficiency type.
